Premarin tablets are used after menopause to reduce moderate to severe hot flashes, treat menopausal changes in and around the vagina, and to help reduce the chances of developing osteoporosis (thin, weak bones).
 

If you use Premarin tablets only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you. If you use Premarin tablets only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.

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ABOUT PREMARIN

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Premarin is a treatment for moderate to severe hot flashes due to menopause that has helped generations of women.

Seven or more moderate to severe hot flashes due to menopause a day could mean it's time to take action.

Ask your doctor about clinically proven Premarin today.

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PREMARIN AND HOT FLASHES

PROVEN RELIEF FOR MODERATE TO SEVERE
POSTMENOPAUSAL HOT FLASHES.

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Premarin has been shown to help reduce the number of moderate to severe hot flashes due to menopause by over 80% at each dose studied* compared to 51% for placebo at 12 weeks.

*Number of patients studied at each dose listed next to each dosage. 0.3 mg (n=30), 0.45 mg (n=32), 0.625 mg (n=27), placebo (n=28).

You may get relief as soon as 4 weeks.

Keep in mind the time it takes to experience relief can be different for different women. In a clinical trial, Premarin significantly reduced the number of moderate to severe hot flashes due to menopause, as compared to placebo. Some women started to experience relief as soon as 4 weeks into treatment.

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At all doses studied (0.3 mg, 0.45 mg, and 0.625 mg), women taking Premarin experienced significantly fewer moderate to severe hot flashes versus placebo.

Talk to your doctor about whether Premarin may be right for you.

Premarin should be used at the lowest effective dose and for the shortest length of time consistent with your treatment goals and risks.

SAFETY AND SIDE EFFECTS

WHAT IS THE MOST IMPORTANT INFORMATION YOU SHOULD KNOW ABOUT PREMARIN?

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.

Do Not Take Premarin If You:

  • Have unusual vaginal bleeding
  • Have or had certain cancers
  • Had a stroke or heart attack
  • Have or had blood clots or liver problems
  • Have a bleeding disorder
  • Are allergic to Premarin or any of its ingredients
  • Think you may be pregnant

ADDITIONAL IMPORTANT INFORMATION:

  • In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus
  • Estrogens increase the risk of gallbladder disease
  • Discontinue estrogen if loss of vision, pancreatitis, liver problems, severe increase in calcium in the blood, or a severe increase in triglycerides occur
  • If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed

The most common (≥5%) side effects:

  • Abdominal pain
  • Asthenia
  • Pain
  • Back pain
  • Headache
  • Flatulence
  • Nausea
  • Depression
  • Insomnia
  • Breast pain
  • Endometrial hyperplasia
  • Leucorrhea
  • Vaginal hemorrhage
  • Vaginitis

These are not all of the possible risks and side effects of Premarin. For more information, see Important Safety Information below and speak with your doctor.

Premarin should be used at the lowest effective dose and for the shortest length of time consistent with your treatment goals and risks. You and your doctor should talk regularly about treatment with Premarin.

IMPORTANT SAFETY INFORMATION AND INDICATION

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause. 

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function). 

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. 

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older. 

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment. 

Premarin should not be used if you have unusual vaginal bleeding, have, or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus. 

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed. 

Serious, but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus, cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, enlargement of benign tumors of the uterus (fibroids), and severe allergic reactions. 

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: new breast lumps; unusual vaginal bleeding; changes in vision or speech; sudden new severe headaches; severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue; swollen lips, tongue, and face. 

Less serious, but common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection. 

INDICATION

Premarin tablets are used after menopause to reduce moderate to severe hot flashes, treat menopausal changes in and around the vagina, and to help reduce the chances of developing osteoporosis (thin, weak bones).

If you use Premarin tablets only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you. If you use Premarin tablets only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.

Please see full Prescribing Information, including BOXED WARNING and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause. 

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function). 

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. 

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older. 

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment. 

Premarin should not be used if you have unusual vaginal bleeding, have, or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus. 

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed. 

Serious, but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus, cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, enlargement of benign tumors of the uterus (fibroids), and severe allergic reactions. 

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: new breast lumps; unusual vaginal bleeding; changes in vision or speech; sudden new severe headaches; severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue; swollen lips, tongue, and face. 

Less serious, but common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection. 

INDICATION

Premarin tablets are used after menopause to reduce moderate to severe hot flashes, treat menopausal changes in and around the vagina, and to help reduce the chances of developing osteoporosis (thin, weak bones).

If you use Premarin tablets only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you. If you use Premarin tablets only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.

Please see full Prescribing Information, including BOXED WARNING and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. Visit http://www.fda.gov/MedWatch or call 1-800-FDA-1088.

Doctors may recommend alternative treatment options to their patients.

*TERMS AND CONDITIONS

By using this Premarin Co-pay Card, you acknowledge that you currently meet the eligibility criteria and will comply with the Terms and Conditions described below:

  • Patients are not eligible to use this Card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veteran Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as "La Reforma de Salud").
  • Patient must have private insurance. Offer is not valid for cash-paying patients. The value of this co-pay card is limited to $55 per use or the amount of your co-pay, whichever is less.
  • This co-pay card is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plan or other private health or pharmacy benefit programs.
  • You must deduct the value of this co-pay card from any reimbursement request submitted to your private insurance plan, either directly by you or on your behalf.
  • Eligible patients will pay a minimum of $30 with a savings of up to $55 per prescription fill. Limit 12 offers per calendar year.
    • If your out-of-pocket cost is $85 or less, you will pay $30 and save up to $55.
    • If your out-of-pocket cost is more than $85, you will save up to $55 with this co-pay card and you must cover the remaining expenses.
  • Maximum savings of $660 per calendar year.
  • You are responsible for reporting use of the co-pay card to any private insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the co-pay card, as may be required. You should not use the co-pay card if your insurer or health plan prohibits use of manufacturer co-pay cards.
  • You must be 18 years of age or older to redeem the co-pay card.
  • This co-pay card is not valid where prohibited by law.
  • Co-pay card cannot be combined with any other savings, free trial or similar offer for the specified prescription.
  • Co-pay card will be accepted only at participating pharmacies.
  • If your pharmacy does not participate, you may be able to submit a request for a rebate in connection with this offer.
  • This co-pay card is not health insurance.
  • Offer good only in the U.S. and Puerto Rico.
  • Co-pay card is limited to 1 per person during this offering period and is not transferable.
  • A co-pay card may not be redeemed more than once per month per patient.
  • No other purchase is necessary.
  • Data related to your redemption of the co-pay card may be collected, analyzed, and shared with Pfizer, for market research and other purposes related to assessing Pfizer's programs. Data shared with Pfizer will be aggregated and de-identified; it will be combined with data related to other co-pay card redemptions and will not identify you.
  • Pfizer reserves the right to rescind, revoke or amend this offer without notice.
  • Offer expires 12/31/2024.

For reimbursement when using a nonparticipating pharmacy/mail order:

Pay for Premarin prescription and mail copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: Pfizer, Attn: Claims Processing Department, IQVIA, Inc., 77 Corporate Drive, Bridgewater, NJ 08807. Be sure to include a copy of the front of your co-pay card, your name, and mailing address.

For help with the Premarin Co-pay Card, call 1-866-410-3700.

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The information provided in this website is intended only for healthcare professionals in the United States. The products discussed herein may have different product labeling in different countries.

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This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

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